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Current Grant Support

NIH-NINDS R21NS135430-01 – Regulation of Schwann Cell Mitochondria Homeostasis in Painful Peripheral Neuropathy. PIs: Campana and Pekkurnaz. Major goals: The foundation for this research project is the discovery that the low-density lipoprotein receptor-related protein (LRP1) in Schwann cells (SCs) dramatically alters mitochondrial properties. 2023- 2025

Veterans Administration I01BX006386-01 –Targeting LRP1 in Neuroinflammation and Neuropathic Pain. PI: Campana. Major goals: To determine whether molecular mediators, generated by injured peripheral nerves, bind the low-density lipoprotein receptor related protein (LRP1) and regulate Schwann cell physiology and painful peripheral neuropathies. 2024-2028

NIH-NCI-NINDS R43CA268700 – Pre-clinical Validation of Phase II Peptide Agonists to Treat and Prevent Chemotherapy Induced Peripheral Neuropathy. PIs: Campana and Gelber. Major goals: To identify second generation small molecules from Alpha-1-Anti-Trypsin peptides that are efficacious in treating chemotherapy induced peripheral neuropathy. 2022-2023

Department of Defense W81XWH 22-1-0722 –Treating Oral Cancer Pain with LRP1 Agonists. PIs: Campana and Ye. Major goals: To determine whether LRP1 modulators can reduce tumor size and thus, reduce facial pain associated with oral cancer. 2022-2025


Veterans Administration 101 RX003363-01A1 –Targeting Schwann cell exosomes for treating neuropathic pain. PI: Campana. Major goals: To isolate Schwann cell derived small extracellular vesicles (pSC EVs) from plasma of rodent with neuropathic pain. Cargo of neuropathic pSC EVs is investigated. 2020-2024

NIH-NIDCR R01DE029493 –Schwann Cell Activation in Oral Cancer Invasion and Neuropathic Pain. PI: Ye, Co-I: Campana. Major goals: To determine whether Schwann cells contribute to oral cancer pain and regulate the extracellular environment. 2020-2025

Locations

Wendy M. Campana, PhD

Department of Anesthesiology and Program in Neuroscience
University of California, San Diego

9500 Gilman Drive, La Jolla, CA 92093

San Diego VA Healthcare System

3350 La Jolla Village Dr, San Diego, CA 92161

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