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Historical and Select Publications

  • Campana WM, Li XQ, Dragojlovic N, Janes J, Gaultier A, Gonias SL (2006) The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: Possible implications in peripheral nerve injury. J Neurosci 26: 11197-11207.  

  • Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou GP, Dolkas J, Myers RR, Gonias SL, Campana WM (2008) A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. J Clin Invest 118:161-172. 

  • Mantuano E, Henry KW, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM (2011) The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci 31(38):13376-13385. 

  • Yoon C, van Niekerk E, Henry K, Ishikawa T, Orita S, Tuszynski MH, Campana WM (2013) Low density lipoprotein receptor related protein 1 (LRP1) dependent cell signaling promotes axonal regeneration. J BIOL CHEM 288:26557-26568. 

  • Orita S, Henry KW, Mantuano E, Yamauchi K, Ishikawa T, DeCorato A, Pollack M, Feltri ML, Wrabetz L, Ellisman M, Takahashi K, Gonias S, Campana WM (2013) Schwann cell LRP1 regulates Remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci 33(13):5590-5602. **Selected for F1000Prime. 

Publications in the Last 5 Years

Small extracellular vesicles from neurons and glia

  • Winston CN, Romero HK, Ellisman M, Nauss S, Julovich DA, Conger T, Hall JR, Campana W, O’Bryant SE, Nievergelt CM, Baker DG, Risbrough VB, Rissman RA (2019) Assessing neuronal and astrocyte derived exosomes from individuals with mild traumatic brain injury for markers of neurodegeneration and cytotoxic activity. Front Neurosci 13: 1005.

  • Gonias SL, Banki MA, Azmoon P, Romero HK, Sigurdson CJ, Mantuano E, Campana WM (2022). Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor LRP1 receptor system. J Biol Chem Jan 25:101642.

  • Sadri S, Hirosawa N, Le J, Romero H, Martellucci S, Kwon HJ, Pizzo D, Ohtori S, Gonias SL, Campana WM (2022) Tumor necrosis factor receptor-1 is selectively sequestered into Schwann cell extracellular vesicles where it functions as TNF-alpha decoy. Glia 70(2):256-272. 

  • Mantuano E, Azmoon A, Banki MA, Sigurdson CJ, Campana WM, Gonias SL (2022) A soluble PrPc derivative and membrane anchored PrPc in extracellular vesicles attenuate innate immunity by engaging the NMDA-R/LRP1 receptor complex. J Immunol 208(1):85-96.

  • Gonias SL, Campana WM (2023) Schwann cell extracellular vesicles: judging a book by its cover. Neural Regen Research  18(2): 325-326.

LRP1 in nerve injury, repair and neuropathic pain

  • Poplawski G, Ishikawa T, Brifault C, Lee-Kubli C, Regestam R, Henry KW, Shiga Y, Kwon HJ, Ohtori S, Gonias SL, Campana WM (2018) Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury. Glia 66(8): 1577-1590.

  • Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E (2018) PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology. J Cell Sci 131(14): pii: jcs217083.

  • Brifault C, Kwon H, Campana WM, Gonias SL (2019) LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing. Glia 67(6): 1210-1224. 

  • Shiga Y, Shiga A, Mesci P, Kwon H, Brifault C, Kim JH, Jeziorski JJ, Nasamran C, Ohtori S, Muotri AR, Gonias SL, Campana WM (2019) Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. Sci Rep 9(1): 19291.

  • Wang Z, Martellucci S, Van Enoo A, Austin D, Gelber C, Campana WM (2022) Systemically administered SP16, a low-density lipoprotein receptor related protein LRP1 agonist demonstrates efficacy for treating acute and neuropathic pain. Faseb J 36 (1):e22093. 

Schwann cells and neuropathic pain

  • Salvo EM, Campana WM, Scheff NN, Nguyen TH, Jeong S, Wall I, Wu A, Zhang S, Kim H, Bhattacharya A, Janal MN, Liu C, Albertson DG, Scmidt BL, Dolan JC, Schnidt RE, Boada MD, Ye Y (2020) Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion. Pain 161: 2592-2602. 

  • Brifault C, Romero H, Van-Enoo A, Pizzo D, Azmoon P, Kwon HJ, Nasamran N, Gonias SL Campana WM (2020). Deletion of the gene encoding the N-Methyl-D-Aspartate Receptor GluN1 subunit in Schwann cells causes ultrastructural changes in Remak bundles and hypersensitivity in pain processing. J Neurosci 40(47):9121-9136. 

  • Ye Y, Jensen DD, Viet CT, Pan HL, Campana WM, Amit M, Boada MD (2022) Advances in Head and Neck Cancer Pain. J Dent Res Apr 13:220345221088527.

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